Battles with Iron: Manganese in Oxidative Stress Protection

Protection against Oxidative Stress

Antioxidant Enzymes and Oxidative Stress in the Erythrocytes of Iron Deficiency Anemic Patients Supplemented with Vitamins

Background: Iron deficiency anemia is one of the major causes of morbidity and mortality worldwide. Evidences from epidemiological and clinical studies suggest a possible correlation between antioxidant levels and the anemic disease risk. The present work is to investigate antioxidant levels and lipid peroxidation in anemic patients. Methods: A number of 30 patients (15 males and 15 females) we...

Iron Therapy and Oxidative Stress

Iron, Oxidative Stress and Health

Iron is an element of crucial importance to living cells. It has incompletely filled ‘d’ orbitals and exists in a range of oxidation states, the most common being ferrous [Fe II (d6)] and ferric [Fe III(d5)] forms. By virtue of this unique electrochemical property, iron is an ideal redox active cofactor for many biological processes and fundamental biochemical activities in all cells. It can as...

Disruption of sitA compromises Sinorhizobium meliloti for manganese uptake required for protection against oxidative stress.

During the initial stages of symbiosis with the host plant Medicago sativa, Sinorhizobium meliloti must overcome an oxidative burst produced by the plant in order for proper symbiotic development to continue. While identifying mutants defective in symbiosis and oxidative stress defense, we isolated a mutant with a transposon insertion mutation of sitA, which encodes the periplasmic binding prot...